An Overview of Introductory and Advanced Survival Analysis Methods in Clinical Applications: Where Have we Come so far?

The time-to-event relationship for survival modeling is considered when designing a study in clinical trials. However, because time-to-event data are mostly not normally distributed, survival analysis uses non-parametric data processing and analysis methods, mainly Kaplan-Meier (KM) estimation models and Cox proportional hazards (CPH) regression models. At the same time, the log-rank test can be applied to compare curves from different groups.

Supportive Oligonucleotide Therapy (SOT) as a Potential Treatment for Viral Infections and Lyme Disease: Preliminary Results.

Antisense therapy is widely used as an alternative therapeutic option for various diseases. RNA interference might be effective in infections, through the degradation of messenger RNA and, therefore, translation process. Hence, proteins essential for microorganisms and viruses' proliferation and metabolism are inhibited, leading to their elimination.

Adoptive transfer of activated immune cells against solid tumors: A preliminary study.

Background: This study presents preliminary results concerning the effectiveness of a novel immunotherapy in cancer. The proposed adoptive cellular therapy product contains a mixture of effector immune cells, specifically macrophages, NK cells, dendritic cells, cytotoxic T lymphocytes and monoclonal antibody producing plasma cells.

Methods: The results were based on both descriptive and inferential statistical analysis of data concerning 17 cancer patients.

Supportive Oligonucleotide Therapy (SOT) as an Alternative Treatment Option in Cancer: A Preliminary Study.

Background/aim: An early evaluation concerning the effectiveness of supportive oligonucleotide therapy (SOT) in cancer as a monotherapy and in combination with other types of treatment.

Patients And Methods: This study evaluated the clinical condition and performance status (Karnofsky-Index) of 95 patients, post-SOT administration. Furthermore, circulating tumor cells (CTCs) from 47 patients' pre- and post-SOT administration were measured and analyzed by repeated-measures ANOVA.

Cancer Comprehensive Analysis in Gastric Carcinoma: Benefits and New Perspectives.

Gastric cancer is one of the most common and deadly cancers worldwide. Screening tests as well as tools for prediction of treatment outcomes and prognosis have been developed, but they have many limitations. The integration of liquid biopsy provided new aspects in screening and diagnosis of gastric cancer.