Influence of intranasal sterile isotonic sea water applications on xylometazoline administration: an experimental study in pigs.

Objective: The aim of this study was to investigate how isotonic sea water solution (Physiomer) affects the structure of porcine nasal mucosa when it is applied simultaneously with vasoconstrictors (xylometazoline) for a prolonged period of time.

Methods: Twenty pigs of the PMR-Landraze breed formed the study group. A solution of xylometazoline 0, 1% (Otrivin spray, Novartis) was sprayed every 8h in both nasal cavities of the pigs, with two applications into each nostril for 28 days.