Pimavanserin reverses multiple measures of anxiety in a rodent model of post-traumatic stress disorder.

Pimavanserin is a highly selective 5-HT inverse agonist in current medical use. Prior studies suggest that 5-HT serotonin receptors may play a role in anxiety and emotional memory. Therefore, pimavanserin was tested in a rat model of PTSD to determine whether it might ameliorate PTSD-like symptoms.

Self-Other Balance in Context: A Quiet Ego May Be Meaningful and Adaptive in Latinx/Hispanic Cultures and Work Settings.

Quiet ego is a relatively novel, increasingly studied, multi-dimensional concept characterized by a compassionate, interdependent worldview and an adaptive balance between self-interest and concern for others. Quiet ego has been associated with a range of characteristics that can promote relationship quality, responding effectively in the face of challenges, and greater well-being. However, it is currently unknown to what extent quiet ego translates across cultures and settings.

The influence of social support on cognitive health in older women: a Women's Health Initiative study.

Social support is associated prospectively with cognitive decline and dementia among the elderly; however, little is known about the impact of social support on healthy neurological aging. The current study investigates whether perceived social support has an influence on neurological health among a large sample of healthy postmenopausal women. Social support and neuropsychological outcomes were measured annually for six years through the Women's Health Initiative Study of Cognitive Aging.

Musical reward across the lifespan.

Music is ubiquitous. Despite the fact that most people find music enjoyable, there are individual differences in the degree to which listeners derive pleasure from music. However, there has been little focus on how musical reward may change across the lifespan.

Increased perceived stress is related to decreased prefrontal cortex volumes among older adults.

Introduction: Several of the brain regions vulnerable to increased levels of stress (i.e., hippocampus and prefrontal cortex) are also known to undergo disproportionate decline during normal aging.

Is there a recovery of decision-making function after frontal lobe damage? A study using alternative versions of the Iowa Gambling Task.

In a previous study, we examined whether frontal patients with impaired decision making on the Iowa Gambling Task (IGT) would recover over time if retested on the IGT. However, a major limitation of repeated administration of the IGT is practice effects, where control participants show improvement with retesting. Therefore, the primary goal of this study was to design two alternative versions of the IGT to eliminate practice effects.

Analgesia or addiction?: implications for morphine use after spinal cord injury.

Opioid analgesics are among the most effective agents for treatment of moderate to severe pain. However, the use of morphine after a spinal cord injury (SCI) can potentiate the development of paradoxical pain symptoms, and continuous administration can lead to dependence, tolerance, and addiction. Although some studies suggest that the addictive potential of morphine decreases when it is used to treat neuropathic pain, this has not been studied in a SCI model.