In vitro effects and mechanisms of action of in .

Background And Aim: African trypanosomiasis poses serious health and economic concerns to humans and livestock in several sub-Saharan African countries. The aim of the present study was to identify the antitrypanosomal compounds from (whole plant) through a bioactivity-guided isolation and investigate the effects and mechanisms of action against ().

Experimental Procedure: Crude extracts and fractions were prepared from air-dried pulverized plant material of using the modified Kupchan method of solvent partitioning.

Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub.

Trypanosomosis and helminthosis, considered as part of neglected tropical diseases, are parasitic infections of public health importance, especially in Africa. Medicinal plants have been used in most parts of Africa, to treat these parasitic infections. The study aims to determine the anti-trypanosomal and anthelminthic properties of Tetrapleura tetraptera (fruit and stembark).

Isolation and Antitrypanosomal Characterization of Furoquinoline and Oxylipin from .

In the absence of vaccines, there is a need for alternative sources of effective chemotherapy for African trypanosomiasis (AT). The increasing rate of resistance and toxicity of commercially available antitrypanosomal drugs also necessitates an investigation into the mode of action of new antitrypanosomals for AT In this study, furoquinoline 4, 7, 8-trimethoxyfuro (2, 3-b) quinoline (compound ) and oxylipin 9-oxo-10, 12-octadecadienoic acid (compound ) were isolated from the plant species (Lam) Zepern and Timler (root), and their in vitro efficacy and mechanisms of action investigated in () the species responsible for AT. Both compounds resulted in a selectively significant growth inhibition of (compound , half-maximal effective concentration EC = 1.

Antitrypanosomal Effects of (Lam.) Zepern. & Timler Extracts on African Trypanosomes.

African trypanosomiasis is a disease caused by the parasitic protozoa of the genus. Despite several efforts at chemotherapeutic interventions, the disease poses serious health and economic concerns to humans and livestock of many sub-Saharan African countries. (Lam.

Ability of Vital and Fluorescent Staining in the Differentiation of Live and Dead Eggs.

This study reports (for the first time) the staining ability of vital (0.4% trypan blue and 1% neutral red) and fluorescent (Hoechst 33258) dyes to differentiate between live and dead () eggs in human urine samples. Since egg is important in disease pathology, diagnosis, transmission, and drug development research, it is essential to be able to easily distinguish live eggs from dead ones.

In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth.

Leishmaniasis is an infectious disease transmitted by the sand fly. It is caused by over 20 different species of Leishmania and has affected over 14 million people worldwide. One of the main forms of control of leishmaniasis is chemotherapy, but this is limited by the high cost and/or toxicity of available drugs.

Low prevalence of Plasmodium and absence of malaria transmission in Conakry, Guinea: prospects for elimination.

Background: Over the past 15 years, mortality and morbidity due to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings. This study addresses the bio-ecology of larval and adult stages of malaria vectors, Plasmodium infection in Anopheles gambiae s.l.