Publications by authors named "Georgijs Nesterovics"
Despite the implementation of next-generation sequencing-based genetic testing on patients with clinical familial hypercholesterolemia (FH), most cases lack complete genetic characterization. We aim to investigate the utility of the polygenic risk score (PRS) in specifying the genetic background of patients from the Latvian Registry of FH (LRFH). We analyzed the whole-genome sequencing (WGS) data of the clinically diagnosed FH patients (n = 339) and controls selected from the Latvian reference population (n = 515).
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on identifying genetic variants associated with familial hypercholesterolemia (FH) in Latvian patients, as there is limited existing data on this condition in Latvia.
- - Whole genome sequencing was conducted on patients from the Latvian Registry of FH, revealing that 20.9% had pathogenic or likely pathogenic variants, primarily in the
- LDLR
- gene.
- - Although many patients had high LDL-cholesterol levels indicative of FH, the low diagnostic yield suggests that other genetic factors or mechanisms may play a role in this population.
Background: Pulmonary vein isolation (PVI) has entrenched itself as one of the main approaches for the treatment of paroxysmal symptomatic atrial fibrillation (AF). Pulmonary vein isolation prevents focal triggers from pulmonary veins from initiating AF paroxysms. As standard-PVI is performed through the inferior vena cava (IVC) approach, through the femoral vein.
View Article and Find Full Text PDF: Over the last five decades cardiac implantable electronic devices (CIED) have become established as the mainstay for the treatment of permanent bradycardias, chronic heart failure and dangerous heart rhythm disturbances. These devices improve survival and quality of life in many patients. However, infections associated with CIED implantation, particularly lead-related infective endocarditis (LRIE), can offset all benefits and make more harm than good for the patient.
View Article and Find Full Text PDFBackground And Aims: Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017).
Methods: The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort.