Risk factors for apathy in Alzheimer's disease: A systematic review of longitudinal evidence.

Background: Apathy is frequent and persistent in Alzheimer's disease (AD), associated with poor prognosis and carer distress; yet our knowledge of risk factors remains limited.

Aims: To identify risk factors associated with apathy incidence and progression in AD over time.

Methods: We systematically reviewed evidence based on longitudinal studies assessing risk factors for apathy in AD up to June 2021.