Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis.

Objective: To evaluate existing evidence for the use of probiotics in preventing antibiotic-associated diarrhoea (AAD) in adults.

Design: Systematic review and meta-analysis of randomised controlled trials (RCTs).

Data Sources: We performed a literature search of the electronic databases CINAHL Plus, EMBASE, MEDLINE (Ovid) and Web of Science from database inception to May 2021 as well as hand searching of trial registries and reference lists of related reviews.