Publications by authors named "Georgia Elna Ambada Ndzengue"
Performance of immunochromatographic and immunoenzymatic techniques in the diagnosis of toxoplasmosis in pregnant women in Cameroon: need for harmonization.
Pan Afr Med J
March 2023
Introduction: in order to contribute to the improvement of the management of toxoplasmosis in pregnant women in Cameroon, performance of two techniques commonly used in the diagnosis of toxoplasmosis was evaluated.
Methods: a total of 541 pregnant women were recruited from seven hospitals in two Regions of Cameroon, of which 63% (341: Batch1) were from health facilities (HF) using a immunochromatographic technique (ICT) as a screening test for toxoplasmosis, and 37% (200: Batch2) from those using an immunoenzymatic technique (IEZ). On each sample, Ig (Immunoglobulin) G (IgG) and IgM were tested by three techniques: a Rapid Diagnostic Test (RDT), an Enzyme Linked Immuno Sorbent Assay (ELISA) and a Vidas Enzyme-linked fluorescent assay taken as reference (VIDAS/ELFA).
Article Synopsis
- Antiretroviral therapy (ART) effectively lowers HIV-1 levels to undetectable but requires lifelong use, as treatment cessation leads to viral rebound due to latent reservoirs in CD4+ T cells.
- Understanding the characteristics of these HIV reservoirs and their variability is crucial for developing a potential cure, with factors like treatment timing and immune response influencing them.
- The research aims to analyze immune and viral profiles of HIV-1 non-B infected adolescents in Cameroon to gather data for HIV cure research, including comparisons with HIV-negative peers.