Publications by authors named "Georgia Deliconstantinos"
Article Synopsis
- Acute Myeloid Leukemia (AML) is a serious illness that often needs strong treatments called chemotherapy, but sometimes these treatments don't work well enough.
- Researchers studied how certain genes related to DNA damage respond in AML cells after chemotherapy using two different medicines: Idarubicin and Cytarabine.
- They found that a gene called PPP1R15A is important for helping cells recover from stress, and when they turned off this gene, the cancer cells didn't survive as well when treated with the chemotherapy, suggesting a way to make the treatment more effective.
Background/aim: The DSL proteins, Serrate and Delta, which act as Notch receptor ligands, mediate signalling between adjacent cells, when a ligand-expressing cell binds to Notch on an adjacent receiving cell. Notch is ubiquitously expressed and DSL protein mis-expression can have devastating developmental consequences. Although transcriptional regulation of Delta and Serrate has been amply documented, we examined whether they are also regulated at the level of translation.
View Article and Find Full Text PDFBackground/aim: The tachykinin mouse hemokinin-1, expressed by the mouse Tac4 gene, produces either analgesia or nociception, interacting with the neurokinin 1 receptor. TAC4 precursor processing is not identical to the processing of the TAC1 precursor, for the release of substance P (amidated undecapeptide). The characterization of the mouse hemokinin-1 sequence was required.
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