Publications by authors named "Georgi Lukose"
Article Synopsis
- Malignant biphasic tumors of the lungs are uncommon, particularly in children, and this study focuses on unique cases involving pleuropulmonary blastoma Type III and an unclassified thoracic neoplasm.
- The pleuropulmonary blastoma was found to have significant DICER1 mutations and other gene variants, while the unclassified tumor exhibited a specific genetic translocation leading to a YAP1::LEUTX fusion, which has associations with cancer development.
- This research emphasizes the value of whole-genome analysis in identifying the biological characteristics and potential treatment targets for rare tumors.
An epidemic caused by an outbreak of mpox (formerly monkeypox) in May 2022 rapidly spread internationally, requiring an urgent response from the clinical diagnostics community. A detailed description of the clinical validation and implementation of a laboratory-developed real-time PCR test for detecting nonvariola Orthopoxvirus-specific DNA based on the newly designed RealStar Zoonotic Orthopoxvirus assay is presented. The validation was performed using an accuracy panel (n = 97) comprising skin lesion swabs in universal transport media and from mpox virus genomic DNA spiked into pooled mpox virus-negative remnant universal transport media of lesion specimens submitted for routine clinical testing in the NewYork-Presbyterian Hospital clinical laboratory system.
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- Classifying liver tumors, especially HCC, can be tough in biopsies, but PSMA helps distinguish them by highlighting blood vessel changes linked to tumors.* -
- A study evaluated archived liver tissues and found that PSMA was positive in 80.9% of HCC cases, showing higher specificity and accuracy compared to CD34 in identifying HCC.* -
- PSMA is not only a good marker for liver cancer but also indicates the presence of new blood vessels, suggesting future research on its use in diagnosis and treatment of liver tumors.*
The significant histologic overlap between diversion colitis and inflammatory bowel disease (IBD) poses a diagnostic challenge. We aimed to identify histologic features that are characteristic of diverted colon segments among patients with IBD and compare them with histologic features identified in IBD colectomies. Archived slides from resected diverted colon segments from patients with (n = 79) and without (n = 80) IBD and the corresponding prior colectomies (n = 52) of the IBD patients were reviewed.
View Article and Find Full Text PDFBackground: Appendiceal inflammation in colectomy is one of the histologic predictors of pouchitis in ulcerative colitis (UC) following ileal pouch anal anastomosis (IPAA). Fecal calprotectin level has been shown to increase 2 months prior to the onset of pouchitis. We evaluated whether inflammation and calprotectin expression in appendiceal specimens correlate with early-onset pouchitis in UC and indeterminate colitis (IC).
View Article and Find Full Text PDFAims: Data regarding expression of intestinal markers in hepatocellular carcinoma (HCC) are limited. We determined the clinicopathological associations of cytokeratin (CK)19, a progenitor liver epithelial cell marker as well as biliary epithelial marker, and intestinal immunohistochemical markers expression in HCC and assessed their prognostic value.
Methods And Results: Tissue sections and/or tissue microarrays (TMAs) from 202 known HCCs were immunostained using CK19, CK20, CDH17, CDX2 and SATB2 antibodies.