Publications by authors named "Georgi Kolishovski"
Article Synopsis
- - The Mouse Phenome Database is a curated repository that provides detailed information and tools for analyzing attributes of various mouse populations, including 657 mouse strains and community standard ontologies.
- - It has evolved from focusing on inbred strains to encompassing diverse populations like the Diversity Outbred and Collaborative Cross, and recently includes data from the International Mouse Phenotyping Consortium.
- - The database offers an interactive tool suite for users to perform analyses such as correlation and trait pattern matching, supporting research on phenotypic variation related to health and disease across different lifespans.
Article Synopsis
- - The Mouse Phenome Database (MPD) is a comprehensive resource that collects and organizes phenotype and genotype data from mouse studies, supported by the NIH and compliant with FAIR data principles.
- - MPD features data from over 6000 mouse strains and populations, incorporating various characteristics related to genetics, behavior, morphology, and disease, and provides detailed metadata to enhance data usability.
- - The database includes analysis tools for users to visualize and aggregate data from different studies, ensuring access to high-quality, reproducible results that are relevant for translational research.
It is well understood that variation in relatedness among individuals, or kinship, can lead to false genetic associations. Multiple methods have been developed to adjust for kinship while maintaining power to detect true associations. However, relatively unstudied are the effects of kinship on genetic interaction test statistics.
View Article and Find Full Text PDFVisualizing regions of conserved synteny between two genomes is supported by numerous software applications. However, none of the current applications allow researchers to select genome features to display or highlight in blocks of synteny based on the annotated biological properties of the features (e.g.
View Article and Find Full Text PDFArticle Synopsis
- - The Mouse Phenome Database (MPD) is a comprehensive online repository that provides primary phenotype data for laboratory mice, allowing for data analysis and visualization through APIs.
- - It includes data on various phenotyping endpoints and disease traits from researchers globally, with a focus on well-curated per-animal information and adherence to public ontologies for consistency.
- - New genetic analysis tools help users explore relationships between genetics and traits, supporting research in areas like trait associations and multi-trait modeling, while ensuring the quality and relevance of studies.
Article Synopsis
- - The Mouse Phenome Database (MPD) is a global resource that offers access to experimental trait data, genotypic variations, protocols, and analysis tools for mouse genetic research.
- - It includes a wide range of phenotyping data for naïve and treated mice, with contributions from researchers worldwide, all rigorously curated for accuracy and accessibility.
- - MPD also supports advanced genetic studies by providing tools for assessing replicability, analyzing trait co-inheritance, and facilitating the creation of new mouse models through genome editing technologies.
Article Synopsis
- The increasing complexity of bioinformatic workflows makes it challenging to reproduce tasks accurately, particularly when using Cytoscape for network visualization and analysis.
- The introduction of the cyREST app and associated libraries allows users to utilize popular programming languages and tools to automate network-related tasks, improving both reproducibility and productivity.
- The paper details cyREST's API and provides examples using Python and R, demonstrating how it can enhance large-scale data analysis and its popularity in the Cytoscape app store, with over 1900 downloads since 2014.