Publications by authors named "Georgi E Salnikov"
A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease.
Oleg V Ardashov Alla V Pavlova Arun Kumar Mahato Yulia Sidorova Ekaterina A Morozova Georgi E Salnikov
ACS Chem Neurosci
October 2019
Article Synopsis
- Researchers synthesized new compounds called monoepoxides from a previously studied monoterpenoid that reduced Parkinson's disease symptoms in animal models.
- One specific epoxide was identified that effectively restored movement in mice with Parkinson's and successfully crossed the blood-brain barrier.
- This epoxide showed strong protective effects on dopamine neurons and could promote the regrowth of these neurons, suggesting its potential as both a treatment and a neuroprotective drug for Parkinson's disease.