Publications by authors named "Georgette Eskander"
Aim: The aim of this study is to investigate the neuroprotective effect of roflumilast, a phosphodiesterase-4 (PDE-4) inhibitor on cognitive impairment induced by doxorubicin (DOX)/cyclophosphamide (CP) combination therapy and to elucidate its modulatory effect on the pyroptosis pathway.
Materials And Methods: Rats were allocated into five groups: a control group, a DOX/CP-intoxicated group, two groups receiving DOX/CP plus low-dose (0.5 mg/kg/day) or high-dose (1 mg/kg/day) roflumilast, and a roflumilast-only group.
Objectives: The objective of this web-based study is to analyze the attributes of bariatric surgery cases ensuing health implications. Additionally, the study seeks to delve into the factors influencing post-bariatric psychological evaluations and the impact of various bariatric surgeries on weight loss and psycho-social assessment scores for patients who had undergone bariatric surgeries within a specific bariatric surgery center in Egypt between January 2017 and January 2024.
Methods: An analytical cross-sectional study recruited 411 adults who had undergone different bariatric procedures by the same surgical team.
Exploring COVID-19 vaccine adverse events among pregnant women: a cross-sectional study, 2022.
Ther Adv Vaccines Immunother
October 2024
Article Synopsis
- Clear and trustworthy information is essential for increasing COVID-19 vaccination acceptance among pregnant women, particularly due to their heightened risk for severe complications from the virus.
- A study conducted in Jeddah, Saudi Arabia, compared pregnant women who received the COVID-19 vaccine to those who did not, assessing adverse events and pregnancy-related complications.
- Results showed that women who were vaccinated (Group B) experienced higher instances of certain complications but had lower COVID-19 rates post-vaccination, indicating the vaccine's potential benefits despite some risks.
Article Synopsis
- The COVID-19 pandemic has led to high morbidity and mortality rates globally, prompting the use of vaccines as a primary control measure, although concerns about safety and adverse events (AEs) have arisen.
- A study conducted in six Arabic countries involved 1,564 participants and surveyed vaccination history, types of vaccines, and AEs using a validated questionnaire.
- The results showed that local AEs were the most common after vaccination, with factors such as age and gender influencing the likelihood of experiencing AEs, while a previous SARS-CoV-2 infection increased the risk of post-vaccination COVID-19.
Anti-cancer conventional chemotherapeutic drugs novel formula progress, nowadays, uses nano technology for targeted drug delivery, specifically tailored to overcome therapeutic agents' delivery challenges. Polymer drug delivery systems (DDS) play a crucial role in minimizing off-target side effects arising when using standard cytotoxic drugs. Using nano-formula for targeted localized action, permits using larger effective cytotoxic doses on a single special spot, that can seriously cause harm if it was administered systemically.
View Article and Find Full Text PDF