Publications by authors named "Georgette Beatriz Paula"
Comparison between two inhibin B ELISA assays in 46,XY testicular disorders of sex development (DSD) with normal testosterone secretion.
Guilherme Guaragna-Filho Antônio Ramos Calixto Georgette Beatriz De Paula Laurione Cândido De Oliveira André Moreno Morcillo
J Pediatr Endocrinol Metab
January 2018
Article Synopsis
- * The study examined serum inhibin B levels in 29 patients diagnosed with various forms of 46,XY DSD using two different ELISA assays (Beckman-Coulter and AnshLabs).*
- The results showed a high interclass correlation (0.915), but significant discrepancies between the assays suggest that the same kit should be used for consistent measurements in patients.*
Article Synopsis
- This study analyzed 408 cases of disorders of sex development (DSD) with ambiguous genitalia over a 23-year period, focusing on diagnosis, age of referral, karyotype, and sex of rearing.
- The majority of cases were 46,XY (61.3%), with common conditions including testicular DSD and ovarian DSD, while congenital adrenal hyperplasia was the leading cause.
- The average age for diagnosis was 31.7 months, with a final sex of rearing predominantly male (238 cases) and only a small percentage (6.6%) requiring sex reassignment.
Background: Ovotesticular disorder of sex development (OT-DSD) (true hermaphroditism) is an anatomopathological diagnosis based on the findings of testicular and ovarian tissues in the same subject, in the same gonad (ovotestis), or in separate gonads. OT-DSD is a rare cause of sex ambiguity, and the most common karyotype is 46,XX; mosaics and chimeras are found only in 10%-20%.
Aim: To report a case of an OT-DSD patient with a rare karyotype constitution.