Publications by authors named "Georges F Dewynter"
Article Synopsis
- A new solid-phase method enables the effective creation of "traceless" sulfahydantoins, resulting in 28 derivatives with high crude purity (over 85%).
- The technique employs parallel synthesis using reductive alkylations, Mitsunobu reactions, and sulfamoylation on oxime resin to selectively substitute sulfahydantoin derivatives at specific positions (N(2) and N(5)).
- The mild conditions used in the reactions prevent racemization, though the yields for disubstituted compounds are lower.
