Publications by authors named "Georgeena Mathew"

Advances in the field of nanobiotechnology are largely due to discoveries in the field of materials. Recent developments in the field of electrochemical biosensors based on transition metal nanomaterials as transducer elements have been beneficial as they possess various functionalities that increase surface area and provide well-defined active sites to accommodate elements for rapid detection of biomolecules. In recent years, transition metal dichalcogenides (TMDs) have become the focus of interest in various applications due to their considerable physical, chemical, electronic, and optical properties.

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Rising concerns of pesticide-induced neurotoxicity and neurodegenerative diseases like Parkinson's, Alzheimer's, and Multiple Sclerosis, are exacerbated by overexposure to contaminated waterbodies. Therefore, evaluating the risk accurately requires reliable monitoring of related biomarkers like dopamine (DA) through electrochemical detection. Layered double hydroxides (LDHs) have shown great potential in sensors.

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Article Synopsis
  • Nitric oxide (NO) is a crucial signaling molecule in cellular functions and cancer physiology, but traditional detection methods struggle with its high reactivity and short lifespan.
  • This study presents a novel sensor using platinum (Pt) nanoparticle-decorated electrochemically reduced graphene oxide (erGO) on a glassy carbon electrode (GCE) to detect NO at low concentrations effectively.
  • The sensor, created using two different methods, showed a significantly higher electrocatalytic current response and a low detection limit of 52 nM, proving its practical use for NO detection.
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An unusual approach is reported herein to fabricate magnetic hematite (α-FeO) decorated electrochemically reduced graphene oxide (α-FeO@erGO) nanocomposite. The method utilizes direct electrochemical reduction of self-assembled, ex-situ synthesized α-FeO anchored GO to erGO (α-FeO@erGO) on glassy carbon electrode (GCE) for selective detection dopamine (DA), an important biomarker of Parkinson's disease. The formation of α-FeO@erGO/GCE has been confirmed by XPS and Raman spectroscopy.

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