Publications by authors named "George W Y Ng"

Article Synopsis
  • Current severe COVID-19 treatments have side effects, and N-acetylcysteine (NAC) is being explored as a safer alternative, though research on its effectiveness in critical cases is limited.
  • A study analyzed data from patients over 18 in ICU with respiratory failure and found that those receiving high-dose NAC (10 g/day) had higher 28-day mortality and fewer ventilator-free days compared to those who did not.
  • After adjusting for variables, the matched analysis showed no significant impact of NAC on 28-day mortality rates or recovery metrics, suggesting it may not be an effective treatment for severe COVID-19 pneumonia.*
View Article and Find Full Text PDF

Background: Early randomized controlled trials have demonstrated the benefits of tight glucose control. Subsequent NICE-SUGAR study found that tight glucose control increased mortality. The optimal glucose target in diabetic and nondiabetic patients remains unclear.

View Article and Find Full Text PDF

Introduction: In early 2020, our hospital responded with high alertness when novel coronavirus SARS-CoV-2 appeared. A hospital-based training programme was rapidly arranged to prepare staff for the imminent threat.

Objective: We developed a hospital-wide multidisciplinary infection control training programme on endotracheal intubation for healthcare workers to minimise nosocomial spread of COVID-19 during this high-stress and time-sensitive risky procedure.

View Article and Find Full Text PDF

To assess the effect from individual component in combinations of steroid, ascorbic acid, and thiamine on outcomes in adults with sepsis and septic shock with component network meta-analysis (NMA). We searched PubMed, EMBASE, and the Cochrane Library Central Register of Controlled Trials from 1980 to March 2021 for randomized controlled trials (RCT) that studied the use of glucocorticoid, fludrocortisone, ascorbic acid, and thiamine in patients with sepsis and septic shock. Citations screening, study selection, data extraction, and risk of bias assessment were independently performed by two authors.

View Article and Find Full Text PDF

Purpose: Use of anticoagulation in patients on ECMO, especially in Chinese, has always been difficult. This study aimed to review the incidence of bleeding, thrombosis, and transfusion requirement in Chinese ECMO patients and to identify risk factors for bleeding complications.

Materials And Methods: This was a retrospective observational study of a tertiary hospital from 2010 to 2018.

View Article and Find Full Text PDF

Background: Intravenous fluid is important for resuscitation and maintenance of circuit flow in patients with extracorporeal membrane oxygenation, but fluid overload is widely recognized as detrimental in critically ill patients. This study aimed to evaluate the association between positive fluid balance and outcomes in adult patients treated with extracorporeal membrane oxygenation.

Methods: This was a retrospective observational study of a tertiary hospital from October 2010 to January 2018.

View Article and Find Full Text PDF

Veno-arterial extracorporeal membrane oxygenation is a form of mechanical circulatory support for patients with refractory decompensated heart failure. Blood is drawn from a large vein and pumped back to a large artery, usually a femoral artery through large bore catheters. When the heart recovers, the extracorporeal membrane oxygenation support can be terminated and the catheters are decannulated.

View Article and Find Full Text PDF

Background: Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related complications. This network meta-analysis summarizes the efficacy and safety of preoxygenation methods in adult patients with acute hypoxemic respiratory failure.

View Article and Find Full Text PDF

Objectives: Despite growing recognition of the importance of speaking up to protect patient safety in critical care, little research has been performed in this area in an intensive care unit (ICU) context. This study explored the communication openness perceptions of Chinese doctors and nurses and identified their perceptions of issues in ICU communication, their reasons for speaking up and the possible factors and strategies involved in promoting the practice of speaking up.

Design: A mixed-methods design with quantitative and sequential qualitative components was used.

View Article and Find Full Text PDF

Introduction: A simulation team-based crew resource management training programme was developed to provide a unique multidisciplinary learning experience for health care professionals in a regional hospital in Hong Kong. In this study, we evaluated how health care professionals perceive the programme.

Methods: A cross-sectional questionnaire survey was conducted in the Multidisciplinary Simulation and Skills Centre at Queen Elizabeth Hospital in Hong Kong.

View Article and Find Full Text PDF

We report a rare complication of factor V deficiency in a patient having Legionella pneumonia. This patient also had other complications like severe acute respiratory distress syndrome, acute kidney injury, and septic shock that required venous-venous extracorporeal membrane oxygenation support. This is the first reported case of acquired factor V deficiency in a patient receiving extracorporeal membrane oxygenation for Legionella pneumonia.

View Article and Find Full Text PDF

Objective: To present the 3-year experience of using venovenous extracorporeal membrane oxygenation for patients with severe respiratory failure in a single centre in Hong Kong.

Design: Case series.

Setting: A 19-bed Intensive Care Unit of a tertiary hospital in Hong Kong.

View Article and Find Full Text PDF