Publications by authors named "George Shakir"
Article Synopsis
- The study investigates the role of the cannabinoid CB1 receptor in atherosclerosis using a transgenic mouse model, focusing on myeloid-specific CB1 signalling.
- Male Cnr1-deficient mice developed smaller atherosclerotic lesions and showed reduced inflammatory responses compared to controls, while differences in females were less significant.
- The findings suggest that impaired CB1 signalling in macrophages could be protective against atherosclerosis in males, with the effects being influenced by sex hormones like oestrogen.
Inflammatory Breast Carcinoma: Elevated microRNA miR-181b-5p and Reduced miR-200b-3p, miR-200c-3p, and miR-203a-3p Expression as Potential Biomarkers with Diagnostic Value.
Sarah Atef Fahim Mahmoud Salah Abdullah Nancy A Espinoza-Sánchez Hebatallah Hassan Ayman M Ibrahim George Shakir
Biomolecules
July 2020
Inflammatory breast cancer (IBC) is a rare yet aggressive breast cancer variant, associated with a poor prognosis. The major challenge for IBC is misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression of microRNAs (miRNAs) in primary samples of IBC and non-IBC tumors using human breast cancer miRNA PCR array.
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