Publications by authors named "George Pyrgos"
Article Synopsis
- Direct lightning strikes can lead to severe injuries, impacting multiple organ systems, and the prognosis varies based on injury severity.
- A 35-year-old man suffered a direct lightning strike while in a portable toilet, leading to unresponsiveness and requiring extensive medical intervention, including CPR and vasopressor support.
- Despite initial recovery, he ultimately succumbed to multi-organ failure due to complications like myocardial damage, lactic acidosis, and extensive burns.
Article Synopsis
- Spontaneous splenic rupture is a rare but serious medical condition often linked to various underlying health issues like infections or neoplasms.
- An unusual case involves a 73-year-old man who developed upper abdominal pain after falling, leading to a diagnosis of splenomegaly and a ruptured spleen via CT angiography.
- During emergency surgery, doctors found significant bleeding in the abdomen and identified the spleen's damage as part of a rare dendritic cell tumor disorder.
Background: Deep inspirations (DIs) can prevent (bronchoprotection; BP) and reverse (bronchodilation; BD) methacholine (Mch)-induced bronchoconstriction, but this effect is reduced or absent in people with asthma or airways hyperresponsiveness (AHR). The mechanisms of this defect are unknown.
Objective: To indirectly examine the role of guanosine 3',5'-cyclic monophosphate (cGMP) by testing the hypothesis that the phosphodiesterase (PDE) V inhibitor, sildenafil, would improve DI-induced BP in individuals with AHR.
In healthy individuals, deep inspirations (DIs) have a potent bronchodilatory ability against methacholine (MCh)-induced bronchoconstriction. This is variably attenuated in asthma. We hypothesized that inability to bronchodilate with DIs is related to reduced airway distensibility.
View Article and Find Full Text PDFWe hypothesized that structural airway remodeling contributes to airways hyperresponsiveness (AHR) in asthma. Small, medium, and large airways were analyzed by computed tomography in 21 asthmatic volunteers under baseline conditions (FEV1 = 64% predicted) and after maximum response to albuterol (FEV1 = 76% predicted). The difference in pulmonary function between baseline and albuterol was an estimate of AHR to the baseline smooth muscle tone (BSMT).
View Article and Find Full Text PDFAbsence of deep inspiration-induced bronchoprotection against inhaled allergen.
Am J Respir Crit Care Med
June 2003
Deep inspiration-induced bronchoprotection appears to be a major mechanism through which airway obstruction by spasmogens is avoided. Loss of bronchoprotection is associated with airway hyper-responsiveness. Individuals with allergic rhinitis and no airway hyperresponsiveness develop obstruction after allergen inhalation.
View Article and Find Full Text PDF