Factors affecting esophageal motility in gastroesophageal reflux disease.

Background: There are conflicting data concerning the effect of gastroesophageal reflux disease (GERD) on esophageal motor function.

Hypothesis: Duration of GERD might affect severity of symptoms, grade of esophageal mucosal injury, and esophageal motor behavior.

Design: Retrospective study of a defined cohort.

Hyperglycemia attenuates erythromycin-induced acceleration of liquid-phase gastric emptying of hypertonic liquids in healthy subjects.

Acute hyperglycemia has been associated with delayed gastric emptying in healthy controls. Erythromycin has recently been found to be a gastrointestinal prokinetic agent in both solids and hypertonic liquids. Our aim was to examine whether the acute steady-state hyperglycemia reduces the erythromycin-induced acceleration of gastric emptying of hypertonic liquids after a fasted state of the stomach in healthy subjects.