Publications by authors named "George Philippos"
Single-cell DNA sequencing (scDNA-seq) enables decoding somatic cancer variation. Existing methods are hampered by low throughput or cannot be combined with transcriptome sequencing in the same cell. We propose HIPSD&R-seq (HIgh-throughPut Single-cell Dna and Rna-seq), a scalable yet simple and accessible assay to profile low-coverage DNA and RNA in thousands of cells in parallel.
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- - Chromothripsis is a process where a single catastrophic event causes significant genomic rearrangements, but its variability across different tumor clones and response to treatments is not well understood.
- - This study investigates chromothripsis in p53-deficient medulloblastoma and neural stem cells, focusing on the genomic and transcriptomic changes involved.
- - The researchers analyze the order of genetic events, explore subclonal variation, and identify how chromothripsis influences cancer development, targeted therapies, and the fitness of neural progenitor cells.