Objectives: Short bowel syndrome (SBS) remains the leading cause of neonatal intestinal failure. Milk fat globule epidermal growth factor-8 (MFG-E8), present in human milk, has homology with epidermal growth factor (EGF), known to enhance adaptation in SBS. In this pilot study, the role of oral MFG-E8 treatment in SBS was explored in neonatal piglets.
View Article and Find Full Text PDFMarine megafauna tend to migrate vast distances, often crossing national borders and pose a significant challenge to managers. This challenge is particularly acute in the Pacific, which contains numerous small island nations and thousands of kilometers of continental margins. The green sea turtle, Chelonia mydas, is one such megafauna that is endangered in Pacific waters due to the overexploitation of eggs and adults for human consumption.
View Article and Find Full Text PDFAnat Rec A Discov Mol Cell Evol Biol
March 2004
Undifferentiated cells have been identified in the prenatal blastocyst, inner cell mass, and gonadal ridges of rodents and primates, including humans. After isolation these cells express molecular and immunological markers for embryonic cells, capabilities for extended self-renewal, and telomerase activity. When allowed to differentiate, embryonic stem cells express phenotypic markers for tissues of ectodermal, mesodermal, and endodermal origin.
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