Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.

Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines showed that englerin A inhibits growth of a subset of tumor cell lines from many lineages, not just renal cell carcinomas. Expression of the TRPC4 cation channel was the cell line feature that best correlated with sensitivity to englerin A, suggesting the hypothesis that TRPC4 is the efficacy target for englerin A.

The effects of sex and grade-point average on emotional intelligence.

This study was conducted to examine the effects of sex and grade-point average (GPA) on emotional intelligence on secondary students as measured by the Emotional Intelligence Inventory (EII). The EII is a 41-item Likert scale based on the original theoretical model of emotional intelligence developed by Salovey and Mayer. An exploratory factor analysis identified four factors, which were named Empathy, Utilization of Feelings, Handling Relationships, and Self-control.

A validation of the emotional intelligence inventory.

The Emotional Intelligence Inventory (EII) was developed to measure emotional intelligence based on the model of Salovey and Mayer. Exploratory factor analyses of the initial pool of items resulted in four factors: Empathy, Utilization of Feelings, Handling Relationships, and Self-control. The present study examined the concurrent validity of the EII and the Emotional Intelligence Scale using responses of 234 college students on both inventories.