Publications by George M Laws

Publications by authors named "George M Laws"

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Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.

Wen Kang Alexei A Podtelezhnikov Keith Q Tanis Stephen Pacchione Ming Su George M Laws

Toxicol Sci

September 2020

Article Synopsis

Early risk assessment of drug-induced liver injury (DILI) is crucial in pharmaceutical development, and researchers have created rat liver biomarkers to predict the potential for high-risk reactive metabolites.
A new in vitro assay using advanced micropatterned coculture (HEPATOPAC) with rat hepatocytes has been developed to identify drugs with lower DILI risk, achieving 81% sensitivity and 90% specificity for detecting hepatotoxicants.
This approach allows for early drug discovery screening, guiding the selection of safer drug candidates while utilizing rat models routinely and human models when needed.

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Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests.

M Vijayaraj Reddy Richard D Storer George M Laws Michael J Armstrong John E Barnum

Environ Mol Mutagen

September 2002

3-Methylindole (3MI), melatonin (Mel), serotonin (Ser), and tryptamine (Tryp) were evaluated in vitro for their potential to induce DNA adducts, DNA strand breaks, chromosomal aberrations (Abs), inhibition of DNA synthesis, and mutations. All compounds produced DNA adducts in calf thymus DNA in the presence of rat liver S9. In cultured rat hepatocytes, all produced DNA adducts but none induced DNA strand breaks.

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