The deleterious effect of bisphenol S on early embryo development of mice.

Purpose: Increasing levels of infertility in Western countries has drawn ever more scientific attention to the role in this trend of endocrine disruptors, such as bisphenol A, a substance now banned in some cases and some countries. Because this substance has been replaced by the structurally similar bisphenol S (BPS), this study focused on the effects of the latter on early mice embryo development.

Methods: Cultures of CD1 mice embryos with varying concentrations of BPS were compared with control blank cultures in order to examine the survival rate of embryos according to BPS concentration and culture day.

Assessment of artificial intelligence model and manual morphokinetic annotation system as embryo grading methods for successful live birth prediction: a retrospective monocentric study.

Purpose: The introduction of the time-lapse monitoring system (TMS) and the development of predictive algorithms could contribute to the optimal embryos selection for transfer. Therefore, the present study aims at investigating the efficiency of KIDScore and iDAScore systems for blastocyst stage embryos in predicting live birth events.

Methods: The present retrospective study was conducted in a private IVF Unit setting throughout a 10-month period from October 2021 to July 2022, and included the analysis of 429 embryos deriving from 91 IVF/ICSI cycles conducted due to infertility of various etiologies.