Publications by authors named "George Jarrouj"
Characterization of a chronic cough in cerebellar ataxia, neuropathy, vestibular areflexia syndrome.
Laryngoscope Investig Otolaryngol
June 2023
Article Synopsis
- CANVAS (Cerebellar ataxia with neuropathy and vestibular areflexia syndrome) is identified as a frequent cause of late-onset ataxia, often accompanied by chronic cough that has significant quality of life impacts.
- In a study of 13 patients, a majority reported a chronic dry cough starting around 16 years before ataxia symptoms, with various triggers and limited response to treatment.
- Imaging showed a high prevalence of esophageal and laryngeal issues, suggesting that chronic cough in CANVAS has complex underlying mechanisms and highlights the need for genetic testing in unexplained chronic cough cases.
Colorectal cancer liver metastases (CRCLM) that present with a replacement histopathological growth pattern (HGP) are resistant to neoadjuvant anti-angiogenic therapy. Surrogate biomarkers are not available to preoperatively identify patients with these tumors. Here we identify differentially expressed genes between CRCLM with a replacement HGP and those with a desmoplastic HGP using RNA sequencing.
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