Publications by authors named "George Ertl"
Background: The role of adaptive immunity, especially CD4(+) T-helper cells, has not yet been systematically investigated in wound healing and remodeling after myocardial infarction (MI). Therefore, we studied whether CD4(+) T cells become activated and influence wound healing after experimental MI in mice.
Methods And Results: When we compared sham versus MI in wild-type (WT) mice, T-cell receptor-dependent activation of both conventional Foxp3(-) and regulatory Foxp3(+) CD4(+) T cells could be demonstrated in heart-draining lymph nodes within the first week after MI.
Article Synopsis
- Patients with myocardial infarction (MI) often underwent echocardiography or cardiac catheterization for assessing left ventricular (LV) function, but many with heart failure (HF) did not receive this assessment.
- The study found that those who had LV assessments were more likely to be prescribed beneficial medications upon discharge, indicating better quality of care.
- Additionally, LV assessment was linked to lower in-hospital mortality rates for both patients with and without heart failure, highlighting its importance in improving patient outcomes.
Background: The risk of sudden death from cardiac causes is increased among survivors of acute myocardial infarction with reduced left ventricular systolic function. We assessed the risk and time course of sudden death in high-risk patients after myocardial infarction.
Methods: We studied 14,609 patients with left ventricular dysfunction, heart failure, or both after myocardial infarction to assess the incidence and timing of sudden unexpected death or cardiac arrest with resuscitation in relation to the left ventricular ejection fraction.