Biomechanical and Endplate Effects on Nutrient Transport in the Intervertebral Disc.

Background: Physical data are lacking on nutrient transport in human intervertebral discs (IVDs), which support regeneration. Our objective was to study nutrient transport in porcine IVDs to determine the effects of biomechanical and physiological factors.

Methods: In vitro testing of whole porcine IVDs was performed under different loading conditions.

Depot antipsychotics: Where do we stand?

Background: Nonadherence to medication is a major problem for patients with schizophrenia. To counter this problem, pharmaceutical companies began developing depot antipsychotics. Although there are currently 5 first-generation and 6 second-generation depot antipsychotics available worldwide, many physicians are still reluctant to use this category of drug initially.