IgM antibodies towards pre-endothelial cells: strong indication for an association with accelerated rejection. A case report.

A 27-year-old woman developed a graft loss due to an accelerated humoral rejection after receiving a blood group identical, human leucocyte antigens (HLA) haploidentical living-related kidney, despite the fact that she did not refer any sensitization event before transplantation. The complement-dependent cytotoxicity and flow cytometry crossmatches were negative for T and B cells. Retrospectively, IgM antibodies against donor precursor endothelial Tie-2(+) cells were detected using a commercially available assay and the pre-transplant serum sample.

Granuloma of the appendiceal stump. An unusual cause of right hemicolectomy.

Granuloma of the appendiceal stump is not a common surgical entity. However, hemorrhage which may lead to right hemicolectomy is rare in fact. We report this case, in order to avoid this kind of overtherapy.