Age at diagnosis is a determinant factor of renal cell carcinoma-specific survival in patients treated with nephrectomy.

Objective: Based on combined data for 4880 patients, 2 previous studies reported that advanced age is a predictor of increased renal cell carcinoma-specific mortality (RCC-SM). We explored the effect of age in cubic spline analyses to identify the age groups with the most elevated risk for renal cell carcinoma (RCC).

Methods: Our study included 3595 patients from 14 European centres who had partial or radical nephrectomies.