Enhanced phenotypes for identifying opioid overdose in emergency department visit electronic health record data.

Background: Accurate identification of opioid overdose (OOD) cases in electronic healthcare record (EHR) data is an important element in surveillance, empirical research, and clinical intervention. We sought to improve existing OOD electronic phenotypes by incorporating new data types beyond diagnostic codes and by applying several statistical and machine learning methods.

Materials And Methods: We developed an EHR dataset of emergency department visits involving OOD cases or patients considered at risk for an OOD and ascertained true OOD status through manual chart reviews.

Effect of pH on lipid oxidation of red onion skin extracts treated with washed tilapia (Oreochromis niloticus) muscle model systems.

The aim of the study was to investigate the effect of pH on the lipid oxidation of red onion skin extracts (ROSEs) treated with washed tilapia muscle model systems (WTMS). Minced and buffered washed samples were prepared at pH 6.3 and 6.

The use of a traditional nonlooping event monitor versus a loan-based program with a smartphone ECG device in the pediatric cardiology clinic.

Background: A smartphone-enabled device has been developed that provides a single-lead electrocardiogram using a portable monitor. The increase in direct-to-consumer medical devices may lead to health disparities affecting members of socially disadvantaged populations.

Objective: Here we provide a single center's experience in the use of this device in a pediatric cardiology clinic using a loan-based program.

Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from .

The cytochrome P450/P450 reductase fusion enzyme CYP505A30 from the thermophilic fungus and its heme (P450) domain were expressed in and purified using affinity, ion exchange, and size exclusion chromatography. CYP505A30 binds straight chain fatty acids (from ∼C10 to C20), with highest affinity for tridecanoic acid ( = 2.7 μM).

A preliminary comparison of two-dimensional speckle tracking echocardiography and pressure-volume loop analysis in patients with Fontan physiology: The role of ventricular morphology.

Objective: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure-volume loop (PVL) analysis.

Food Safety Impacts from Post-Harvest Processing Procedures of Molluscan Shellfish.

Post-harvest Processing (PHP) methods are viable food processing methods employed to reduce human pathogens in molluscan shellfish that would normally be consumed raw, such as raw oysters on the half-shell. Efficacy of human pathogen reduction associated with PHP varies with respect to time, temperature, salinity, pressure, and process exposure. Regulatory requirements and PHP molluscan shellfish quality implications are major considerations for PHP usage.

Effect of Sildenafil on Pressure-Volume Loop Measures of Ventricular Function in Fontan Patients.

Unlabelled: Sildenafil has been reported to improve exercise capacity in Fontan patients, but the physiologic mechanisms behind these findings are not completely understood. The objective of this study was to study the acute effect of sildenafil on pressure-volume loop (PVL) measures of ventricular function in Fontan patients. Patients after Fontan operation who were presenting for a clinically indicated catheterization were enrolled.

Melody pulmonary valve bacterial endocarditis: experience in four pediatric patients and a review of the literature.

Objectives: The objectives of this manuscript are two-fold: (a) to describe the clinical characteristics and management of four pediatric patients with bacterial endocarditis (BE) after Melody pulmonary valve implantation (MPVI); and (b) to review the literature regarding Melody pulmonary valve endocarditis.

Background: There are several reports of BE following MPVI. The clinical course, BE management and outcome remain poorly defined.

The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.

We report the crystal structure of the FAD/NADPH-binding domain (FAD domain) of the biotechnologically important Bacillus megaterium flavocytochrome P450 BM3, the last domain of the enzyme to be structurally resolved. The structure was solved in both the absence and presence of the ligand NADP(+), identifying important protein interactions with the NADPH 2'-phosphate that helps to dictate specificity for NADPH over NADH, and involving residues Tyr974, Arg966, Lys972 and Ser965. The Trp1046 side chain shields the FAD isoalloxazine ring from NADPH, and motion of this residue is required to enable NADPH-dependent FAD reduction.

Equation of state for a partially ionized gas. III.

The derivation of equations of state for fluid phases of a partially ionized gas or plasma is addressed from a fundamental point of view. The results of the Thomas-Fermi model always yield pressures which are less than or equal to that of an ideal Fermi gas. On the other hand, the spherical cellular model shows significant "overpressure" relative to the ideal Fermi gas in certain regions of low density and low temperature.

Variability and resource utilization of bedside three-dimensional echocardiographic quantitative measurements of left ventricular volume in congenital heart disease.

Objectives: This study evaluated the variability and time resource utilization of bedside 3-dimensional echocardiographic left ventricular volume analysis (3D-LVVA) in congenital heart disease (CHD). Background. There are currently limited data on the resource utilization and variability of 3D-LVVA in the CHD.

Bose-Einstein condensation in the relativistic ideal Bose gas.

The Bose-Einstein condensation (BEC) critical temperature in a relativistic ideal Bose gas of identical bosons, with and without the antibosons expected to be pair-produced abundantly at sufficiently hot temperatures, is exactly calculated for all boson number densities, all boson point rest masses, and all temperatures. The Helmholtz free energy at the critical BEC temperature is lower with antibosons, thus implying that omitting antibosons always leads to the computation of a metastable state.

Improved quantum hard-sphere ground-state equations of state.

The London ground-state energy formula as a function of number density for a system of identical boson hard spheres, corrected for the reduced mass of a pair of particles in a "sphere-of-influence" picture, and generalized to fermion hard-sphere systems with two and four intrinsic degrees of freedom, has a double-pole at the ultimate regular (or periodic, e.g., face-centered-cubic) close-packing density usually associated with a crystalline branch.

Equation of state for a partially ionized gas. II.

The derivation of equations of state for fluid phases of a partially ionized gas or plasma is addressed from a fundamental point of view. A spherical cellular model is deduced for the hot curve limit (or ideal Fermi gas). Next the Coulomb interactions are added to the spherical cellular model for general ionic charge Z.

Factors effecting manubrium-regeneration in hydromedusae (Coelenterata).

1. Umbrellar fragments of the leptomedusaCampanularia johnstoni with or without parts of the radial canal demonstrate a gradient in the potential for manubrium regeneration and in regeneration time. 2.