Neurodevelopment of Autism: Critical Periods, Stress and Nutrition.

Autism spectrum disorder (ASD) is a neurodevelopmental disability that presents significant challenges in communication and behavior. ASD prevalence exceeds 2% among eight-year-old children and is at similar levels globally. We propose that critical periods during fetal development and early postnatal years establish the conditions for either neurotypical development or the emergence of autism through mechanisms that influence immune function or delay neuronal development.

Elucidating the dynamics of carbamazepine uptake using date pit-derived activated carbon: A comprehensive kinetic and thermodynamic analysis.

Water contamination with pharmaceuticals such as Carbamazepine (CBZ) presents a significant environmental challenge. This study investigates the use of activated carbon derived from waste date pits (DPAC) for the removal of CBZ from water. The impact of several parameters such as pH, temperature, CBZ concentration, and flow rate on the adsorption were assessed.

Nutritional Aspects in the Neurodevelopment of Autism: Folate, Stress, and Critical Periods.

Autism spectrum disorder (ASD) is a developmental disability that can create significant challenges in behavior and communication. The prevalence of ASD is over 2% among 8-year-old children and the prevalence is similar across the globe. We suggest there are multiple critical periods during the fetal period and early post-natal years that set conditions for neurotypical development or for autism, via mechanisms that impact immunity.

Eliminating hazardous pollutants: treatment options for dioxins and surfactants from water and wastewater: an updated review.

Surfactants and dioxins are increasingly being released into the environment due to their excessive usage and their improper disposal. These pollutants cause considerable harm to both humans and the natural environment. Therefore, their removal from water and wastewater, which form major pathways for their transmission, is necessary.

Vascular complications after peripheral veno-arterial extracorporeal life support cannulation in cardiogenic shock.

Background: Extra Corporeal Life Support (ECLS) is an evolving therapy in therapy-resistant cardiogenic shock (CS). Vascular cannulation in emergency situations can be accomplished through puncture of the femoral vessels by specialised teams. Since lower limb ischemia constitutes one of the major complications following cannulation, a distal perfusion cannula (DPC) has emerged as standard of care.

Neuroprotection of retinal ganglion cells using the activation of the endogenous cannabinoid signaling system in mammalian eyes.

Cannabinoid and glutamatergic signaling systems in the human retina coexist and greatly influence one another. Under glaucomatous conditions, excess levels of glutamate accrete in the retinal ganglion cell (RGC) layer. The present study tests the putative neuroprotective effect mediated by cannabinoids at the CB1 and CB2 receptors.

Occurrence and hazard assessment of natural radioactivity in drinking water in South Lebanon.

This study is intended to assess the natural radioactivity in the drinking water in the southern region of Lebanon and to determine its suitability for human consumption. In this context, activity concentrations for gross alpha, gross beta, U, U, and radon from selected drinking water sources, wells, and springs and the corresponding tap water, in the area under investigation, were determined during both the wet and the dry seasons. The maximum recorded activities of gross alpha, gross beta, and radon measured using liquid scintillation counter were found to be 374.

Antibacterial activity of chitosan nano-composites and carbon nanotubes: A review.

Bacteriological contamination of water sources is a major challenge that has a detrimental impact on both the environment and human health. This imposes the search for the most efficient disinfectant. Despite their antibacterial efficiency, traditional methods can often form disinfection byproducts through their reaction with organic and inorganic compounds.

[Laser surgery on varicose veins].

Introduction: With the development of medicine, technical inventions have been intoduced into the therapy of varicose veins, such as ultrasound examination and laser treatment.

Patients And Methods: Over 11 years 1729 laser surgery were performed on varicose veins. Junctions of saphenous veins, saphenous stems and perforator veins were treated with lasers, but reticular and spider veins were treated with other methods.

The fate of selected pharmaceuticals in solar stills: Transfer, thermal degradation or photolysis?

The increase in demand for, and disposal of, pharmaceuticals, positively correlated with the growing human population, has led to the emergence of contaminants with high environmental and health impacts. Several developing countries that endure problems related to water sufficiency and/or quality resort to the use solar stills as an affordable water treatment method. This research is aimed at investigating the fate of five chemically distinct pharmaceuticals that might pervade solar stills; ibuprofen (IBU), diclofenac (DCF), carbamazepine (CBZ), ampicillin (AMP) and naproxen (NPX).

Coagulation of highly turbid suspensions using magnesium hydroxide: effects of slow mixing conditions.

Laboratory experiments were carried out to study the effects of slow mixing conditions on magnesium hydroxide floc size and strength and to determine the turbidity and total suspended solid (TSS) removal efficiencies during coagulation of highly turbid suspensions. A highly turbid kaolin clay suspension (1,213 ± 36 nephelometric turbidity units (NTU)) was alkalized to pH 10.5 using a 5 M NaOH solution; liquid bittern (LB) equivalent to 536 mg/L of Mg(2+) was added as a coagulant, and the suspension was then subjected to previously optimized fast mixing conditions of 100 rpm and 60 s.

Precipitation softening: a pretreatment process for seawater desalination.

Reduction of membrane fouling in reverse osmosis systems and elimination of scaling of heat transfer surfaces in thermal plants are a major challenge in the desalination of seawater. Precipitation softening has the potential of eliminating the major fouling and scaling species in seawater desalination plants, thus allowing thermal plants to operate at higher top brine temperatures and membrane plants to operate at a reduced risk of fouling, leading to lower desalinated water costs. This work evaluated the use of precipitation softening as a pretreatment step for seawater desalination.

Do biological-based strategies hold promise to biofouling control in MBRs?

Biofouling in membrane bioreactors (MBRs) remains a primary challenge for their wider application, despite the growing acceptance of MBRs worldwide. Research studies on membrane fouling are extensive in the literature, with more than 200 publications on MBR fouling in the last 3 years; yet, improvements in practice on biofouling control and management have been remarkably slow. Commonly applied cleaning methods are only partially effective and membrane replacement often becomes frequent.

Hollow-fiber membrane bioreactor for the treatment of high-strength landfill leachate.

Performance assessment of membrane bioreactor (MBR) technology for the treatability of high-strength landfill leachate is relatively limited or lacking. This study examines the feasibility of treating high-strength landfill leachate using a hollow-fiber MBR. For this purpose, a laboratory-scale MBR was constructed and operated to treat leachate with a chemical oxygen demand (COD) of 9000-11,000 mg/l, a 5-day biochemical oxygen demand (BOD5) of 4000-6,000 mg/l, volatile suspended solids (VSS) of 300-500 mg/l, total nitrogen (TN) of 2000-6000 mg/l, and an ammonia-nitrogen (NH3-N) of 1800-4000 mg/l.

[5-year experience with varicose vein laser surgery].

Introduction: The incidence of varicose veins in the lower limb is relatively frequent in Europe including Hungary.

Aim: Authors report their 5-year experience in varicose vein laser surgery focusing with regards to recurrence and complication rates.

Patients And Methods: Surgery was performed on 647 lower limbs in 546 patients with an age between 17 and 80 years.

5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians.

No pharmacological therapy is approved to treat methamphetamine physical dependence, but it has been hypothesized that serotonin (5-HT)-enhancing drugs might limit the severity of withdrawal symptoms. To test this hypothesis, we used a planarian model of physical dependence that quantifies withdrawal as a reduction in planarian movement. Planarians exposed to methamphetamine (10 μM) for 60 min, and then placed (tested) into drug-free water for 5 min, displayed less movement (i.

Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells.

Bilberry (European blueberry) has been reported to have many biological effects, including anticancer activity. In this study, we investigated the antiproliferative effects of bilberry extract in relation to its ability to induce apoptosis and affect microtubule assembly and organization in MCF7 human breast cancer cells. We observed that bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.

Modeling the formation of trihalomethanes in drinking waters of Lebanon.

The current research aims at developing predictive models for trihalomethane (THM) formation in Lebanon based on field-scale investigations as well as laboratory controlled experimentations. Statistical analysis on field data revealed significant correlations for TTHM with chlorine dose, Specific UV-A, and UV(254) absorbing organics. Simulated distribution system-THM tests showed significant correlations with applied chlorine dose, total organic carbon, bromides, contact time, and temperature.

Osteopontin is proinflammatory in experimental autoimmune uveitis.

Purpose: Osteopontin (OPN) has been implicated in inflammatory and wound-healing processes. Increased OPN mRNA levels have been reported in experimental autoimmune uveitis (EAU), but the function of OPN in the inflamed eye is unknown. The purpose of this study was to investigate the role of OPN in the pathogenesis of EAU.

Removal of low-concentration phosphorus using a fluidized raw dolomite bed.

Raw dolomite powder, obtained from dolomitic rocks, was evaluated for its efficiency in removing low concentrations of phosphate present in various water and wastewater matrices. A variety of experimental setups and process variables were tested, in an attempt to determine the optimal scheme (fluidized bed) that will be used to accomplish the objectives of the study. Test influents, including distilled water (DW), synthetic groundwater (SGW), tap water (TW), and sodium-hydroxide (NaOH)-alkalized wastewater treated with liquid bittern (STSE-B) and wastewater treated with lime (STSE-L) were used to assess the effect of influent parameters on the quality of the effluent generated.