Effect of single and combination therapy on methanol extracts of Khaya senegalensis stem bark, Vernonia amygdalina leaves and Garcinia kola seed in Leptospira interrogans-infected mice.

Ethnopharmacological Relevance: Pastoralists in Nigeria mix Garcinia kola seed (GK), Khaya senegalensis stem bark (KS), and Vernonia amygdalina leaves (VA) to treat leptospirosis.

Aim: To determine the in vitro and in vivo effect on single and combination therapy on Leptospira interrogans-infected mice.

Materials And Methods: Evaluation of in vitro assay for anti-leptospiral motility of the extracts was carried out in triplicates.