Publications by authors named "George Adam"

Introduction: Favorable short- and long-term outcomes have been reported for lumbar intervertebral total disc replacement (L-TDR). However, there is little evidence regarding the uptake of L-TDR in practice. The objective of this study was to analyze Australian-based population trends in L-TDR over the past 5 years.

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Intramedullary screws (IMS) have become a viable option for metacarpal fracture fixation. To further appraise their utility, this study assessed clinical and patient-reported short- and medium-term outcomes of IMS fixation for extra-articular metacarpal fractures. A retrospective cohort study was performed in a series of 32 patients (with a total of 37 fractures) who underwent metacarpal fracture fixation over a 42-month period between January 2020 and July 2023.

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Article Synopsis
  • Intramedullary screw fixation is becoming a popular method for treating phalangeal and metacarpal fractures due to less tendon disturbance and quicker recovery times.
  • A study analyzing 46 fractures in 37 patients over three years found low complication rates and high patient satisfaction regarding the technique.
  • The results suggest that intramedullary screw fixation is a safe, effective, and potentially more cost-effective alternative to traditional plate fixation for certain hand fractures.
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  • This study evaluated the short- and medium-term outcomes of using intramedullary compression screw fixation for middle phalangeal fractures in 20 patients.
  • Results showed a high total active motion (246°), low disability and pain scores, and a quick return to work (62.5 days), along with only one complication.
  • The conclusion indicates that this fixation method is effective, providing good recovery and minimal complications compared to other fixation methods.
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Zoo management techniques for captive birds, such as flight restraint and enclosure type, may affect behavioral performance and are consequently worthy of investigation. Flamingos are amongst the most popular of zoo-housed birds and, as such, research into their captive management and associated behavioral responses are widely applicable to many thousands of individuals. As a highly social species, understanding social bonds and behavior of the individual bird and the flock overall can help inform decisions that support husbandry and population management.

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The simulation of stochastic reaction-diffusion systems using fine-grained representations can become computationally prohibitive when particle numbers become large. If particle numbers are sufficiently high then it may be possible to ignore stochastic fluctuations and use a more efficient coarse-grained simulation approach. Nevertheless, for multiscale systems which exhibit significant spatial variation in concentration, a coarse-grained approach may not be appropriate throughout the simulation domain.

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Breakthroughs in artificial intelligence (AI) hold enormous potential as it can automate complex tasks and go even beyond human performance. In their study, McKinney et al. showed the high potential of AI for breast cancer screening.

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A Trajectory Data Warehouse is a central repository of large amount of data focusing on moving objects, which have been collected and integrated from multiple sources with spatial and temporal dimensions as the main metrics of analysis. By adding semantic-related contextual information, it is converted to a Semantic Trajectory Data Warehouse. It transforms raw trajectories to valuable information that can be utilized for decision-making purposes in ubiquitous applications.

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  • Cancer is a major global health issue, and personalizing drug treatment through computational modeling can significantly boost recovery chances for patients.
  • Predicting how patients will respond to drugs is complex due to data limitations and algorithm deficiencies, but advances in deep learning offer hope for better prediction models.
  • This review discusses the challenges and improvements in drug response prediction, emphasizing accessible machine learning techniques for clinicians and non-experts, while highlighting the potential of new data sources and rapid drug combination discovery to enhance cancer treatment.
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  • Variations in physiological conditions can change how molecular interactions occur between biological compartments, leading to new understandings of these changes.
  • CrosstalkNet is a web-based tool designed to visualize and analyze complex biological networks, making it easier for researchers to identify and study interactions specific to certain conditions.
  • In a case study, CrosstalkNet was used to analyze gene-expression profiles from breast tumors and normal tissue, revealing insights into the interactions between tumor epithelial and stromal cells.
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