Publications by authors named "George A Jones"
Background: Pseudoarthrosis after spinal fusion is an important cause of pain, neurologic decline, and reoperation.
Methods: The Healthcare Cost and Utilization Project State Inpatient Databases were queried in New York, California, Florida, and Washington for adult patients who had undergone new spinal fusion from 2009 to 2011. In accordance with the Healthcare Cost and Utilization Project methods series and analysis guidelines, generalized linear mixed effects models were used to estimate the odds of experiencing postoperative pseudoarthrosis as a function of multivariable patient characteristics, comorbidities, and surgical approach.
Article Synopsis
- Patients with HIV are at a higher risk for developing non-Hodgkin lymphomas, particularly AIDS-related diffuse large B-cell lymphoma (AR-DLBCL), which is the focus of this study on mTOR pathway activity.
- The study analyzed tissue samples from 126 AR-DLBCL patients, using immunohistochemistry to assess two specific indicators of mTOR pathway activation, p70S6K and pPTEN, along with pPRAS40 in a subgroup.
- Results showed high positivity rates for the p70S6K markers, particularly with the Ser240/244 epitope, indicating significant mTORC1 pathway activity in most patients, especially among younger males.