Publications by authors named "Georgadze Z"

Aim: To study the role of interventricular septum (IVS) in kinetics of left ventricular (LV) and right ventricular (RV) contraction in IHD patients with chronic cardiac failure (CCF).

Material And Methods: Standard equilibrium biventricular radioventriculography was used for the study of an inotropic function of LVand RV myocardium in 117 IHD patients with CCF of NYHA FC I-IV (mean age 58+/-4.1 years).

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The article discusses diagnostic difficulties in patients with acute abdominal pain. The author adduces data on the frequency of late diagnostics of pleuropneumonia and diaphragmatic pleuritis in patients with abdominal syndrome before admission, and in the admission department of an urgent aid hospital. The analysis of the causes of delayed diagnosis of lung and pleura diseases is exemplified with 2 clinical observations.

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The article discusses difficulties in diagnostics of some acute vascular diseases of abdominal organs, associated with abdominal pain. The analysis of the reasons for late diagnosis of mesenterial thrombosis and dissecting aneurysm of the abdominal aorta is based on 2 clinical observations.

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The article discusses diagnostic difficulties in acute abdominal pain. The author adduces data on the frequency of diagnostic errors in diagnostics of coronary heart disease (CHD) before admission and in the admission department of an urgent aid hospital. The analysis of the causes of delayed diagnosis in patients with CHD and acute myocardial infarction is exemplified with 3 clinical observations.

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At present chronic obstructive lung diseases (COLD) occupy a prominent place in the morbidity and mortality of the adult population, with regarding the more and more increasing influence of aggressive environmental factors (sulfur dioxide, nitrogen, ozone, black smog and smoking). Due to the fact that clinical symptoms develop in patients with COLD at its late stages when there are irreversible changes in not only the bronchopulmonary apparatus, but, to a greater extent, the cardiovascular system; the efficiency of performed therapy is rather little. This shows it necessary to diagnose myocardial contractile disorders in such patients as soon as possible as the routine accessible cardiac study techniques (ECG, EchoCG) are of low informative value due to significant emphysema.

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Skin biopsy is the most significant method for diagnosis of microcirculatory disorders in diabetes mellitus of type 2 (DM2) and ischemic heart disease (IHD). This method provides earlier detection of microcirculatory changes which is essential for prophylaxis of life-threatening vascular complications and early treatment. 29 IHD and DM2 patients were examined.

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The aim of the study was to assess prestarium effects on systolic and diastolic cardiac functions in 38 patients with ischemic heart disease and chronic cardiac failure (NYHA functional class II-IV) by biventricular balanced radioventriculography. Both left and right ventricular diastolic dysfunction was found. A course of prestarium treatment caused different alterations in ventricular contractility.

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The paper presents current views on ischemia-reperfusion and mechanisms of its development. Their role in the development of the hibernating myocardium is shown. Possible clinical manifestations of these conditions and currently available diagnostic techniques are assessed.

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Because little is known about disordered metabolism of uric acid as a pathogenetic mechanism of renal damage in non-insulin-dependent diabetes mellitus (NIDDM) it was studied in 75 NIDDM and 48 IDDM patients. Clinical examination of the patients included evaluation of purin metabolism according to serum uric acid, diurnal urine excretion, uric acid clearance. Hyperuricemia occurred more frequently in NIDDM.

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Besides the known factors contributing to the pathogenesis of diabetic nephropathy, the role of immune mechanisms in types I and II diabetes is discussed of late; the contribution of autoimmune mechanisms to pathogenesis of noninsulin-dependent diabetes (NIDDM) is virtually unknown. Seventy-six patients with NIDDM and 48 with insulin-dependent condition were examined. Under study were levels of antibodies to FxIA and renal glomerular basal membrane antigens in the blood sera of donors and patients with types I and II diabetes, as well as concentrations, size, and pathogenicity of immune complexes.

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