Publications by authors named "Georg Schwanitz"
Background: The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of acute and long-term morbidity and mortality worldwide despite global efforts in containment, prophylaxis, and therapy. With unprecedented speed, the global scientific community has generated pivotal insights into the pathogen and the host response evoked by the infection. However, deeper characterization of the pathophysiology and pathology remains a high priority to reduce morbidity and mortality of coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFHigh-content analysis (HCA) converts raw light microscopy images to quantitative data through the automated extraction, multiparametric analysis, and classification of the relevant information content. Combined with automated high-throughput image acquisition, HCA applied to the screening of chemicals or RNAi-reagents is termed high-content screening (HCS). Its power in quantifying cell phenotypes makes HCA applicable also to routine microscopy.
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- PML nuclear bodies (NBs) play a crucial role in nuclear pathways, but their specific biochemical functions remain unclear.
- The study utilized live cell imaging and mathematical modeling to assess the assembly dynamics of PML isoforms at NBs, revealing that they exhibit varied exchange rates and identifying PML V as a key scaffolding component.
- Additionally, factors such as SUMOylation and ATP levels were found to influence the dynamics of protein turnover at NBs, paving the way for understanding the mechanisms involved in the targeting and regulation of proteins within these nuclear domains.