Crossover randomized comparison of intravenous versus intravenous/oral mesna in soft tissue sarcoma treated with high-dose ifosfamide.

Purpose: We conducted our study to determine the pharmacokinetics (PK) and clinical efficacy of oral mesna in patients receiving ifosfamide for soft tissue sarcoma.

Experimental Design: Seventeen patients were enrolled in a randomized prospective Phase I/II study. Seventeen patients were exposed to study medication.

Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects.

Purpose: The antiepileptic drugs (AEDs) retigabine (RGB) and lamotrigine (LTG) undergo predominantly N-glucuronidation and renal excretion. This study was performed to evaluate potential pharmacokinetic interactions between both AEDs.

Methods: Twenty-nine healthy male subjects participated in the study.