From Strain to Loads: Development of a Measurement Solution for Wind Turbine Transmission Input Loads during Drivetrain Testing.

As wind energy is paving the way for the energy transition from fossil to renewable energy sources, the ongoing trend of increasing the rated power of wind turbines aims to reduce the overall cost of wind energy. The resulting increase in drivetrain loads motivates the need for wind turbine (WT) drivetrain testing in the development phase of critical components such as the WT main gearbox (GB). While several WT system test benches allow for the application of emulated rotor loads in six degrees of freedom (6-DOF), the drivetrain input loads can significantly differ from the GB 6-DOF input loads due to the design of the drivetrain under test.

Sensor Screening Methodology for Virtually Sensing Transmission Input Loads of a Wind Turbine Using Machine Learning Techniques and Drivetrain Simulations.

The ongoing trend of building larger wind turbines (WT) to reach greater economies of scale is contributing to the reduction in cost of wind energy, as well as the increase in WT drivetrain input loads into uncharted territories. The resulting intensification of the load situation within the WT gearbox motivates the need to monitor WT transmission input loads. However, due to the high costs of direct measurement solutions, more economical solutions, such as virtual sensing of transmission input loads using stationary sensors mounted on the gearbox housing or other drivetrain locations, are of interest.

Development and validation of a parametric human mandible model to determine internal stresses for the future design optimization of maxillofacial implants.

Large segmental mandible bone defects still represent a challenge for endogenous regeneration. Despite the bone's capacity to heal in many clinical situations, bone defects over a critical size do not heal spontaneously. An emerging treatment of critically sized mandibular defects is the implantation of individually manufactured scaffolds consisting of biodegradable magnesium alloys.

Model-Based Estimation of the Strength of Laser-Based Plastic-Metal Joints Using Finite Element Microstructure Models and Regression Models.

Plastic-metal joints with a laser-structured metal surface have a high potential to reduce cost and weight compared to conventional joining technologies. However, their application is currently inhibited due to the absence of simulation methods and models for mechanical design. Thus, this paper presents a model-based approach for the strength estimation of laser-based plastic-metal joints.

Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group.

The heterogeneity of early stage CLL challenges prognostication, and refinement of prognostic indices for risk-adapted management in this population is essential. The aim of the multicenter, prospective CLL1 trial was to explore a novel prognostic model (CLL1-PM) developed to identify risk groups, separating patients with favorable from others with dismal prognosis. A cohort of 539 clinically, biochemically, and genetically characterized Binet stage A patients were observed until progression, first-line treatment, or death.

Life cycle assessment and sustainable engineering in the context of near net shape grown components: striving towards a sustainable way of future production.

Technical product harvesting (TEPHA) is a newly developing interdisciplinary approach in which bio-based production is investigated from a technical and ecological perspective. Society's demand for ecologically produced and sustainably operable goods is a key driver for the substitution of conventional materials like metals or plastics through bio-based alternatives. Technical product harvesting of near net shape grown components describes the use of suitable biomass for the production of technical products through influencing the natural shape of plants during their growth period.

Observational study of adjuvant therapy with capecitabine in colon cancer.

Objective: This observational study was conducted to document the safety of capecitabine-based adjuvant therapy in patients with resected colon cancer under routine clinical conditions.

Research And Design Methods: ML20431 was a prospective, multicenter, non-interventional, observational study. It was designed to answer five research questions relating to safety, dosage and administration, and discontinuation from capecitabine-based adjuvant therapy.

Solitary pulmonary plasmacytoma: report of two cases.

We report two cases of solitary plasmacytoma of the lung. Computed tomographic scan disclosed in case A a solid tissue formation in a cystic pulmonary lesion and in case B a solitary nodule. Suggesting aspergilloma in A and pulmonary malignancy in B diagnostic thoracotomies were performed and the respective findings were resected.

Nitric oxide pathways in human bladder carcinoma. The distribution of nitric oxide synthases, soluble guanylyl cyclase, cyclic guanosine monophosphate, and nitrotyrosine.

Background: Nitric oxide (NO) is produced by a group of synthase enzymes (NOS). By means of different pathways, NO exerts several functions in benign and malignant human bladder tissues. The current paper describes the NO/guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP) and the NO/oxidative pathways in human bladder tissues.

Low sensitivity of the ki-ras polymerase chain reaction for diagnosing pancreatic cancer from pancreatic juice and bile: a multicenter prospective trial.

Purpose: Early detection of pancreatic cancer using molecular markers may improve outcome. Mutations of the ki-ras oncogene are detected in 70% to 90% of pancreatic adenocarcinomas. A prospective, partially blinded, multicenter diagnostic trial was performed to test the sensitivity and specificity of the ki-ras polymerase chain reaction (PCR) analysis of pancreatic juice and bile specimens.