Publications by authors named "Georg Eulenburg"
Background: Teriflunomide is a once-daily oral disease-modifying therapy (DMT) for the treatment of relapsing-remitting multiple sclerosis (RRMS). Only limited information is available about its real-world use and changes over time.
Objectives: To collect real-world data on teriflunomide use in clinical routine (and comparison to the previously conducted study TAURUS-MS).
Article Synopsis
- Rv2140c is a protein in Mycobacterium tuberculosis with an unknown function, but its structure has been determined through high-resolution crystallography.
- The protein forms a dimeric complex and is similar in structure to proteins that bind phosphatidylethanolamine, suggesting its involvement in lipid metabolism.
- Additionally, the small molecule locostatin attaches to Rv2140c's binding site and is shown to inhibit the growth of Mycobacterium smegmatis, a model organism.
The human pathogenic yeast Candida glabrata harbors more than 20 surface-exposed, epithelial adhesins (Epas) for host cell adhesion. The Epa family recognizes host glycans and discriminates between target tissues by their adhesin (A) domains, but a detailed structural basis for ligand-binding specificity of Epa proteins has been lacking so far. In this study, we provide high-resolution crystal structures of the Epa1A domain in complex with different carbohydrate ligands that reveal how host cell mucin-type O-glycans are recognized and allow a structure-guided classification of the Epa family into specific subtypes.
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