Publications by authors named "Geordie Zimniak"
Article Synopsis
- The extracellular matrix is crucial for how stem cells differentiate and maintain their environment, but its formation and assembly process is not well understood.
- Researchers discovered that blood cells, specifically a type called plasmatocytes, help create the basement membrane of the Drosophila ovarian germline stem cell niche.
- Blocking or removing these plasmatocytes during larval development leads to defective adult niches with too many stem cells, highlighting the importance of blood cell interactions in forming and maintaining the stem cell environment.
The transition from immotile epithelial cells to migrating cells occurs in all organisms during normal embryonic development, as well as during tumour metastasis. During Drosophila oogenesis, border cells (BCs) are recruited and delaminate from the follicular epithelium. This process is triggered by the polar cells (PCs), which secrete the cytokine Unpaired (Upd) and activate the JAK/STAT pathway in neighbouring cells, turning them into invasive BCs.
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