Publications by authors named "Geok Ying Chun"
Background: Medication burden and complexity have been longstanding problems in chronically ill patients. However, more data are needed on the extent and impact of medication burden and complexity in the transfusion-dependent thalassaemia population.
Aim: The aim of this study was to determine the characteristics of medication complexity and polypharmacy and determine their relationship with drug-related problems (DRP) and control of iron overload in transfusion-dependent thalassaemia patients.
Article Synopsis
- The study reviews the impact of poor compliance with iron-chelation therapy (ICT) on health outcomes and quality of life in thalassemia patients, emphasizing its significance due to risks associated with iron overload.
- Out of 4917 studies examined, 20 were included, showing ICT compliance rates ranging from approximately 21% to 100%, depending on the medication used.
- Higher compliance is associated with lower serum ferritin levels and reduced risks of liver and cardiac diseases, as well as improved health-related quality of life, but caution is advised due to limited evidence.
Thalassemia is among the most common genetic disorders globally and many patients suffer from iron overload (IOL) complications that mainly affect the heart, liver and endocrine system. These events may be further complicated by drug-related problems (DRP), an inherent issue among patients with chronic diseases. The study aimed to evaluate the burden, associated factors and impacts of DRP in transfusion-dependent thalassemia (TDT) patients.
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