Publications by authors named "Geoffrey R Schiebinger"
An epithelial-mesenchymal transition (EMT) occurs in almost every metazoan embryo at the time mesoderm begins to differentiate. Several embryos have a long record as models for studying an EMT given that a known population of cells enters the EMT at a known time thereby enabling a detailed study of the process. Often, however, it is difficult to learn the molecular details of these model EMT systems because the transitioning cells are a minority of the population of cells in the embryo and in most cases there is an inability to isolate that population.
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- Cumulative somatic mutations may impact aging by disrupting the networks that control cell function and structure.
- A study on cardiomyocytes indicated that older cells showed increased transcriptional variability.
- However, research on four types of hematopoietic cells did not find significant age-related changes in gene expression noise or cell variability, suggesting that regulatory instability may be more relevant in nonrenewing tissues.