Efficacy and safety of methionine aminopeptidase 2 inhibition in type 2 diabetes: a randomised, placebo-controlled clinical trial.

Aims/hypothesis: This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m) and type 2 diabetes (HbA 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l).

Methods: Participants were randomised (via a centralised interactive web response system) to placebo, 1.

Esophageal dysfunction in patients with atypical chest pain investigated with esophageal scintigraphy and myocardial perfusion imaging: an outcome study.

Background: The objectives of this study were to determine the role of esophageal scintigraphy (ES) and myocardial perfusion imaging (MPI) in patients with atypical chest pain investigated for ischemic heart disease (IHD).

Methods And Results: One hundred five consecutive patients with atypical chest pain were investigated by dual-isotope MPI (1-day rest-stress protocol). Within a 10-day period, each patient also had liquid and semisolid ES performed with dynamic imaging over a 2-minute period for each phase.