Publications by authors named "Geoffrey Migault"
The vestibular system in the inner ear plays a central role in sensorimotor control by informing the brain about the orientation and acceleration of the head. However, most experiments in neurophysiology are performed using head-fixed configurations, depriving animals of vestibular inputs. To overcome this limitation, we decorated the utricular otolith of the vestibular system in larval zebrafish with paramagnetic nanoparticles.
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- The brain's endogenous activity is influenced by the arrangement and interaction of neurons in assemblies, but how this affects overall brain data statistics was unclear.
- Researchers recorded the activity of about 40,000 neurons in zebrafish larvae and used a model called the compositional Restricted Boltzmann Machine (cRBM) to analyze the data.
- This model successfully identified around 200 neural assemblies, allowing for insights into brain states and connectivity, and it can be applied to data from other large-scale neuronal recording methods.
The vestibular apparatus provides animals with postural and movement-related information that is essential to adequately execute numerous sensorimotor tasks. In order to activate this sensory system in a physiological manner, one needs to macroscopically rotate or translate the animal's head, which in turn renders simultaneous neural recordings highly challenging. Here we report on a novel miniaturized, light-sheet microscope that can be dynamically co-rotated with a head-restrained zebrafish larva, enabling controlled vestibular stimulation.
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