Cerebral Malaria (CM) is associated with the complex neurological syndrome, whose pathology is mediated by severe inflammatory processes following infection with Plasmodium falciparum. Coenzyme-Q (Co-Q) is a potent anti-inflammatory, anti-oxidant, and anti-apoptotic agent with numerous clinical applications. The aim of this study was to elucidate the role of oral administration of Co-Q on the initiation or regulation of inflammatory immune response during experimental cerebral malaria (ECM).
View Article and Find Full Text PDFBackground: Industrial wastewater is a human health hazard upon exposure. Aquatic organisms in contaminated wastewater may accumulate the toxic elements with time. Human population living in informal settlements in Nairobi industrial area risk exposure to such toxic elements.
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View Article and Find Full Text PDFLevels of Mercury (Hg), Lead (Pb), Cadmium (Cd), Chromium (Cr), Nickel (Ni) & Thallium (Tl) were established in wastewater & soil samples obtained from 8 sites in open drainage channels at Nairobi industrial area, Kenya. Ultra-trace inductively coupled plasma mass spectroscopy (ICP-MS) was used for metal analysis. Temperature, pH & turbidity of wastewater ranged from 16.
View Article and Find Full Text PDFUnhygienic practices have been associated with the spread of parasitic and bacterial infections in rural areas. This study was designed to verify the link between the frequencies of malaria and typhoid fever with selected rural practices in Njoro District, Kenya. A cross-sectional study involving observations, questionnaires and interviews was conducted to determine the socio-economic variables and practices/lifestyles in 336 randomly selected homesteads.
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