CT-based internal density calibration for opportunistic skeletal assessment using abdominal CT scans.

CT-based opportunistic skeletal assessment complements current osteoporosis diagnosis. Quantitative assessment by internal density calibration overcomes the limitations of phantom-based calibration. We sought to establish and validate an internal calibration technique using abdominal CT scans and establish reproducibility precision for three density calibration techniques.

Concurrent Assessment of Cartilage Morphology and Bone Microarchitecture in the Human Knee Using Contrast-Enhanced HR-pQCT Imaging.

Osteoarthritis (OA) is a prevalent articular disease characterized by whole joint degradation, including articular cartilage and bone. Presently, no single imaging modality is well suited to concurrently capture these changes. Recent ex vivo animal studies have demonstrated the efficacy of utilizing contrast agents in conjunction with micro-CT as a means of evaluating cartilage and bone alterations concurrently, though no work as of yet has been performed in large animal models or humans.