Publications by authors named "Geoffrey Guenther"

Article Synopsis
  • Point-of-care testing (PoCT) is evaluated as a beneficial alternative for diagnosing and treating critically ill children with cerebral malaria in Malawi.
  • In a study of 193 children, over half (52.1%) had abnormal PoCT results, impacting clinical interventions in only 16.9% of cases.
  • Higher mortality risks were observed in patients with specific conditions like hypoglycemia and hyperlactatemia, highlighting the need for further research on PoCT's effectiveness in improving patient outcomes.
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Severe congenital neutropenia caused by jagunal homolog 1 () mutation is a rare condition resulting from maturation arrest secondary to endoplasmic reticulum stress response from impaired neutrophil protein glycosylation. Here, we report a case of a 4-year-old boy who presented with a history of recurrent infections and manifestations, including recurrent intracranial hemorrhage. A review of similar cases reported in the literature indicates that a bleeding diathesis has not been previously described in these patients.

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Background: Standard treatment for both uncomplicated and severe malaria is artemisinin derivatives. Delayed parasite clearance times preceded the appearance of artemisinin treatment failures in Southeast Asia. Most worldwide malaria cases are in sub-Saharan Africa (SSA), where clinically significant artemisinin resistance or treatment failure has not yet been detected.

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Artesunate therapy for severe malaria syndromes has been associated with post-treatment hemolysis and anemia. We defined post-malaria anemia as any decrease in hematocrit between the index hospitalization for severe malaria and 1 month after. We determined the incidence and severity of post-malaria anemia in Malawian children surviving cerebral malaria (CM) by analyzing hospital and follow-up data from a long-standing study of CM pathogenesis.

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