Evaluation of lived experience Peer Support intervention for mental health service consumers in Primary Care (PS-PC): study protocol for a stepped-wedge cluster randomised controlled trial.

Background: The demand for mental health services in Australia is substantial and has grown beyond the capacity of the current workforce. As a result, it is currently difficult for many to access secondary healthcare providers. Within the secondary healthcare sector, however, peer workers who have lived experience of managing mental health conditions have been increasingly employed to intentionally use their journey of recovery in supporting others living with mental health conditions and their communities.

OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis.

Unlabelled: Treatment for complications associated with the hemodynamic consequences of decompensated cirrhosis remains suboptimal. Terlipressin, the latest pharmacological management of hepatorenal syndrome-acute kidney injury (HRS-AKI), targets the vasopressin system but has serious side effects. OCE-205 is a novel peptide designed to target the vasopressin receptor system as a mixed V1a agonist/antagonist, resulting in effective partial agonism without V2 agonism.

OCE-205, A Novel, Selective Vasopressin Receptor Mixed Agonist-Antagonist: Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics from a Phase 1 Study in Healthy Volunteers.

Background: OCE-205, a novel, selective vasopressin V1a receptor mixed agonist/antagonist with no V2 receptor activity, may treat the portal hypertension-related complications of end-stage liver disease with an improved therapeutic profile over currently utilized nonselective full-agonist vasopressin analogs.

Objectives: This Phase 1, double-blind, placebo-controlled, within-dose-group randomized trial investigated the safety, tolerability, and pharmacokinetic/pharmacodynamic profiles of OCE-205 in healthy adults.

Methods: Subjects received a single intravenous dose of OCE-205 0.

Partial vasopressin 1a receptor agonism reduces portal hypertension and hyperaldosteronism and induces a powerful diuretic and natriuretic effect in rats with cirrhosis and ascites.

The vasopressin system has emerged as a therapeutic focus for lowering portal hypertension and reducing splanchnic vasodilation in patients with refractory ascites. Clinically available vasopressin agonists are limited by preferential selectivity for V1 receptors that also have steep concentration-response curves with potential risks of excess vasoconstriction and/or complete antidiuretic effects. OCE-205 is a novel, selective, partial V1a receptor agonist with mixed agonist/antagonist activity and no V2 receptor activation at therapeutic doses.

Empirical validation of ELM trained neural networks for financial modelling.

The purpose of this work is to compare predictive performance of neural networks trained using the relatively novel technique of training single hidden layer feedforward neural networks (SFNN), called Extreme Learning Machine (ELM), with commonly used backpropagation-trained recurrent neural networks (RNN) as applied to the task of financial market prediction. Evaluated on a set of large capitalisation stocks on the Australian market, specifically the components of the ASX20, ELM-trained SFNNs showed superior performance over RNNs for individual stock price prediction. While this conclusion of efficacy holds generally, long short-term memory (LSTM) RNNs were found to outperform for a small subset of stocks.

Barriers to use of refractive services in Mozambique.

Purpose: Uncorrected refractive error remains a leading cause of visual impairment (VI) across the globe with Mozambique being no exception. The establishment of an optometry profession in Mozambique that is integrated into the public health system denotes significant progress with refractive services becoming available to the population. As the foundations of a comprehensive refractive service have now been established, this article seeks to understand what barriers may limit their uptake by the general population and inform decision making on improved service delivery.

The development of a public optometry system in Mozambique: a Cost Benefit Analysis.

Background: The economic burden of uncorrected refractive error (URE) is thought to be high in Mozambique, largely as a consequence of the lack of resources and systems to tackle this largely avoidable problem. The Mozambique Eyecare Project (MEP) has established the first optometry training and human resource deployment initiative to address the burden of URE in Lusophone Africa. The nature of the MEP programme provides the opportunity to determine, using Cost Benefit Analysis (CBA), whether investing in the establishment and delivery of a comprehensive system for optometry human resource development and public sector deployment is economically justifiable for Lusophone Africa.

Forced sex, rape and sexual exploitation: attitudes and experiences of high school students in South Kivu, Democratic Republic of Congo.

This paper reports on fieldwork carried out in 2011 with the aim of investigating the attitudes and reported behaviour of Congolese high school students concerning sexual relationships. A total of 56 boys and girls aged 16-20 from two urban and two rural high schools in South Kivu Province took part in focus groups, and 40 of these were subsequently interviewed individually. The majority of boys felt that they were entitled to sex from their girlfriends and that if persuasion was unsuccessful, the use of force was legitimate; this, in their minds, did not constitute rape.

Field data: distributions and costs of road-traffic fatalities in South Africa.

Background: Road-traffic crashes and fatalities constitute major social and economic issues in South Africa. They are a major cause of morbidity and mortality comparable to HIV/AIDS, homicides, and some chronic diseases.

Methods: Road-traffic accident data for the year 2003 obtained from the Department of Transport, Pretoria, South Africa were used for this study.

The economics of landmine clearance in Afghanistan.

This paper presents an economic evaluation of landmine clearance in Afghanistan. The main benefits comprise increased agricultural output, saved transport time and running costs, saved human casualties and the saved costs of supporting refugees and displaced persons. An investment of US$100 million between 1988 and 1998 is estimated to provide annual benefits of $50.