Publications by authors named "Genying Zhou"
Article Synopsis
- Prediction of the malignant potential of gastrointestinal stromal tumors (GIST) remains challenging, despite several histopathological criteria proposed in older literature.
- A study of 73 GIST cases identified a significant correlation between mitotic count and the tumor's malignant potential, emphasizing the importance of this metric in histopathological diagnosis.
- The findings suggest using Ki-67 index and cellularity as key indicators for malignancy, along with mitotic count, even when other features appear benign.
Recently some reports have suggested that gastrointestinal stromal tumors (GIST) might originate from the interstitial cells of Cajal or differentiate into them because they express c-kit and/or CD34 and indicated that the majority of previously diagnosed smooth muscle tumors (SMT) actually belong to GIST, but are not true SMT. We, therefore, detected c-kit, CD34, SMA, and S-100 in 106 Chinese cases of gastrointestinal tumors, which were histopathologically diagnosed as smooth muscle tumors originally, to demonstrate the immunophenotypes of these tumors. The results showed that 73 cases had immunoreaction with c-kit and/or CD34, of which 48 cases showed coexpression with either SMA or S-100 or with both.
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